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Crystal structure of a lysine biosynthesis enzyme, Lysx, from thermus thermophilus HB8
Analyse Crystal structure of a lysine biosynthesis enzyme, Lysx, from thermus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1UC8
- Type
- protein
- Length
- 505 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2
- Source
- Thermus thermophilus
- Molecule
- lysine biosynthesis enzyme
- Pockets
- 3 · best druggability 0.56
Structure
x-ray diffraction · resolution 2 · 2 distinct chains · 39% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | lysine biosynthesis enzyme | protein | 254 | 39% helix, 26% strand | — |
| B | lysine biosynthesis enzyme | protein | 251 | 39% helix, 26% strand | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 251 | 0.56 | 0.78 | 31 | empty |
| 2 | 101 | 0.40 | 0.77 | 19 | empty |
| 3 | 100 | 0.38 | 0.76 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1903 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 1UC8 · Crystal structure of a lysine biosynthesis enzyme, lysx, from thermus thermophilus HB8 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 1UC8 · PDBe 1UC8
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