Research workbench

Crystal structure of the murine cytomegalovirus MHC-I homolog m144

Analyse Crystal structure of the murine cytomegalovirus MHC-I homolog m144 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1U58
Type: protein
Length: 320 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.9
Source: Murid herpesvirus 1; Mus musculus
Molecule: MHC-I homolog m144; beta-2-microglobulin
Pockets: 5 · best druggability 0.69

Structure

x-ray diffraction · resolution 1.9 · 2 distinct chains · 13% helix, 47% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	MHC-I homolog m144	protein	222	19% helix, 45% strand	—
B	beta-2-microglobulin	protein	98	0% helix, 50% strand	—

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	583	0.69	0.78	57	empty
2	241	0.53	0.76	28	empty
3	61	0.37	0.79	13	empty
4	58	0.29	0.74	16	empty
5	57	0.26	0.72	10	empty

Interfaces

1 interface between chains.

A–B · 1103 Å² buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1U58 · Crystal structure of the murine cytomegalovirus MHC-I homolog M144 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 1U58 · PDBe 1U58

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.