Research workbench
H7 Haemagglutinin
Analyse H7 Haemagglutinin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1TI8
- Type
- protein
- Length
- 480 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3
- Source
- Influenza A virus
- Molecule
- hemagglutinin
- UniProt
- Q6GYW3, Q701T7
- Ligands
- MAN, NAG, NDG
- Pockets
- 3 · best druggability 0.65
Structure
x-ray diffraction · resolution 3 · 2 distinct chains · 23% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | hemagglutinin | protein | 314 | 9% helix, 37% strand | Q6GYW3 |
| B | hemagglutinin | protein | 166 | 50% helix, 13% strand | Q701T7 |
Ligands and binding sites
- MAN · alpha-D-mannopyranose · sugar · 5 copies · chains A
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A, B
- NDG · 2-acetamido-2-deoxy-alpha-D-glucopyranose · sugar · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 276 | 0.65 | 0.82 | 25 | empty |
| 2 | 75 | 0.43 | 0.81 | 26 | empty |
| 3 | 102 | 0.43 | 0.78 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 2866 Ų buried · 39 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 1TI8 · H7 haemagglutinin · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6GYW3
- Every structure of UniProt Q701T7
- Elsewhere: RCSB PDB 1TI8 · PDBe 1TI8 · UniProt Q6GYW3 · UniProt Q701T7
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