Research workbench
Crystal structure of Arabidopsis N-amino acetyltransferase 2 bound to HEPES, Acetyl CoA, GABA, and glycerol
Analyse Crystal structure of Arabidopsis N-amino acetyltransferase 2 bound to HEPES… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 8XJF
- Type
- protein
- Length
- 206 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2
- Source
- Arabidopsis thaliana
- Molecule
- GCN5-related N-acetyltransferase 8
- EC
- 2.3.1.48
- UniProt
- Q9ZV06
- Ligands
- ABU, ACO
- Pockets
- 3 · best druggability 0.70
Structure
x-ray diffraction · resolution 2 · 1 distinct chain · 33% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | GCN5-related N-acetyltransferase 8 (EC 2.3.1.48) | protein | 206 | 33% helix, 26% strand | Q9ZV06 |
Ligands and binding sites
- ABU · Gamma-amino-butanoic acid · ligand · chains A
- ACO · Acetyl coenzyme *A · ligand · chains A
- EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid · additive · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 540 | 0.70 | 0.79 | 41 | EPE, ACO |
| 2 | 203 | 0.51 | 0.76 | 20 | empty |
| 3 | 71 | 0.34 | 0.76 | 20 | empty |
Compared structures
- Q9ZV06 · AlphaFold monomer V2.0 prediction for probable acetyltransferase NATA1-like (Q9ZV06) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9ZV06
- Elsewhere: RCSB PDB 8XJF · PDBe 8XJF · UniProt Q9ZV06
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