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Structure of S. hygroscopicus aminotransferase MppQ complexed with pyridoxal-5'-phosphate (PLP)

Analyse Structure of S. hygroscopicus aminotransferase MppQ complexed with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 8TN2
Type: protein
Length: 775 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.75
Source: Streptomyces hygroscopicus
Molecule: PLP-dependent aminotransferase MppQ
UniProt: Q643B9
Pockets: 12 · best druggability 0.56

Structure

x-ray diffraction · resolution 1.75 · 2 distinct chains · 45% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	PLP-dependent aminotransferase MppQ	protein	389	46% helix, 16% strand	Q643B9
B	PLP-dependent aminotransferase MppQ	protein	386	45% helix, 17% strand	Q643B9

Pockets

12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	185	0.56	0.80	31	empty
2	162	0.55	0.81	38	empty
3	132	0.55	0.82	22	empty
4	146	0.54	0.81	24	empty
5	114	0.42	0.77	31	empty

Interfaces

1 interface between chains.

A–B · 3041 Å² buried · 49 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (cofactor).

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q643B9
Elsewhere: RCSB PDB 8TN2 · PDBe 8TN2 · UniProt Q643B9

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