Research workbench
Tropomyosin-receptor kinase fused gene protein (TRK-fused gene protein; TFG) Low Complexity Domain (residues 237-327) G269V mutant, amyloid fiber
Analyse Tropomyosin-receptor kinase fused gene protein (TRK-fused gene protein; TFG)… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 8TEQ
- Type
- protein
- Length
- 825 residues
- Chains
- 30
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.84
- Source
- Homo sapiens; Purpureocillium lilacinum
- Molecule
- TRK-fused gene protein Low Complexity Domain G269V mutant
- UniProt
- A0A2U3DNX3, Q92734
- Pockets
- 3 · best druggability 0.57
Structure
electron microscopy · resolution 2.84 · 2 distinct chains · 0% helix, 58% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E, G, I, K, M, O, Q, S, U, W, Y, 0, 2 | TRK-fused gene protein Low Complexity Domain G269V mutant | protein | 29 | 0% helix, 59% strand | A0A2U3DNX3, Q92734 |
| B, D, F, H, J, L, N, P, R, T, V, X, Z, 1, 3 | TRK-fused gene protein Low Complexity Domain G269V mutant | protein | 26 | 0% helix, 58% strand | A0A2U3DNX3, Q92734 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 550 | 0.57 | 0.73 | 71 | empty |
| 2 | 142 | 0.40 | 0.73 | 32 | empty |
| 3 | 72 | 0.30 | 0.73 | 17 | empty |
Interfaces
84 interfaces between chains.
- K–O · 1267 Ų buried · 42 hydrogen bonds · protein-protein
- G–K · 1266 Ų buried · 42 hydrogen bonds · protein-protein
- Q–U · 1265 Ų buried · 42 hydrogen bonds · protein-protein
- S–W · 1263 Ų buried · 42 hydrogen bonds · protein-protein
- M–Q · 1263 Ų buried · 42 hydrogen bonds · protein-protein
Compared structures
- Q92734 · AlphaFold monomer V2.0 prediction for protein tfg (Q92734) · a predicted model of the same protein · chain B against A, TM-score 0.32
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A2U3DNX3
- Every structure of UniProt Q92734
- Elsewhere: RCSB PDB 8TEQ · PDBe 8TEQ · UniProt A0A2U3DNX3 · UniProt Q92734
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