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Structure of hantaan orthohantavirus (HTNV) polymerase bound to 5'vRNA

Analyse Structure of hantaan orthohantavirus (HTNV) polymerase bound to 5'vRNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 8P1N
Type: protein + RNA
Length: 1,292 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.79
Source: Hantaan orthohantavirus; SYNTHETIC CONSTRUCT
Molecule: RNA-directed RNA polymerase L; RNA (5'-R(P*AP*GP*UP*AP*G)-3')
EC: 2.7.7.48, 3.1.-.-
UniProt: P23456
Pockets: 20 · best druggability 0.75

Structure

electron microscopy · resolution 2.79 · 2 distinct chains · 49% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA-directed RNA polymerase L (EC 2.7.7.48, 3.1.-.-)	protein	1287	49% helix, 12% strand	P23456
B	RNA (5'-R(PAPGPUPAP*G)-3')	rna	5	—	—

Pockets

20 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	652	0.75	0.81	46	empty
2	1062	0.75	0.78	91	empty
3	662	0.70	0.78	54	empty
4	448	0.68	0.80	42	empty
5	293	0.61	0.79	41	empty

Interfaces

1 interface between chains.

A–B · 722 Å² buried · 14 hydrogen bonds · protein-nucleic

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P23456
Elsewhere: RCSB PDB 8P1N · PDBe 8P1N · UniProt P23456

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