Research workbench
Cryo-EM imaging scaffold subunits A and B used to display KRAS G12C complex with GDP
Analyse Cryo-EM imaging scaffold subunits A and B used to display KRAS G12C complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 8G3K
- Type
- protein
- Length
- 285 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.2
- Source
- synthetic construct; Thermoplasma acidophilum
- Molecule
- Cob_adeno_trans domain-containing protein; Cryo-EM imaging scaffold subunit B with DARPin…
- UniProt
- O58404
- Pockets
- 3 · best druggability 0.49
Structure
electron microscopy · resolution 2.2 · 2 distinct chains · 81% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cob_adeno_trans domain-containing protein | protein | 136 | 83% helix, 0% strand | O58404 |
| B | Cryo-EM imaging scaffold subunit B with DARPin - RCG-33 | protein | 149 | 79% helix, 0% strand | — |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 229 | 0.49 | 0.75 | 25 | empty |
| 2 | 131 | 0.46 | 0.78 | 23 | empty |
| 3 | 67 | 0.28 | 0.73 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 643 Ų buried · 6 hydrogen bonds · protein-protein
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O58404
- Elsewhere: RCSB PDB 8G3K · PDBe 8G3K · UniProt O58404
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