Research workbench
Cryo-EM structure of BCL10 CARD - MALT1 DD filament
Analyse Cryo-EM structure of BCL10 CARD - MALT1 DD filament in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 8CZO
- Type
- protein
- Length
- 4,268 residues
- Chains
- 44
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 4.3
- Source
- Homo sapiens
- Molecule
- Mucosa-associated lymphoid tissue lymphoma translocation protein 1; B-cell…
- EC
- 3.4.22.-
- UniProt
- Q9UDY8, O95999
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · resolution 4.3 · 2 distinct chains · 68% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p, q, r, s, t, u, v | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) | protein | 88 | 57% helix, 0% strand | Q9UDY8 |
| A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V | B-cell lymphoma/leukemia 10 | protein | 106 | 77% helix, 0% strand | O95999 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 626 | 0.83 | 0.88 | 94 | empty |
| 2 | 212 | 0.82 | 0.95 | 35 | empty |
| 3 | 207 | 0.82 | 0.95 | 36 | empty |
| 4 | 211 | 0.82 | 0.95 | 35 | empty |
| 5 | 206 | 0.82 | 0.95 | 35 | empty |
Interfaces
104 interfaces between chains.
- j–G · 701 Ų buried · 0 hydrogen bonds · protein-protein
- m–J · 700 Ų buried · 0 hydrogen bonds · protein-protein
- t–Q · 699 Ų buried · 0 hydrogen bonds · protein-protein
- q–N · 688 Ų buried · 0 hydrogen bonds · protein-protein
- r–O · 688 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 22 disulfide (disulfide).
Compared structures
- 8CZO · Cryo-EM structure of BCL10 card - MALT1 dd filament · the same entry in another collection · chain J against J, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UDY8
- Every structure of UniProt O95999
- Elsewhere: RCSB PDB 8CZO · PDBe 8CZO · UniProt Q9UDY8 · UniProt O95999
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