Research workbench
Human Urea Transporter UT-A (N-Terminal Domain Model)
Analyse Human Urea Transporter UT-A (N-Terminal Domain Model) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 8BLO
- Type
- protein
- Length
- 1,056 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.9
- Source
- Homo sapiens
- Molecule
- Urea transporter 2
- UniProt
- Q15849
- Ligands
- LMN, PLD
- Pockets
- 11 · best druggability 0.79
Structure
electron microscopy · resolution 2.9 · 1 distinct chain · 66% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, B | Urea transporter 2 | protein | 352 | 66% helix, 1% strand | Q15849 |
Ligands and binding sites
- LMN · Lauryl Maltose Neopentyl Glycol · ligand · 15 copies · chains A, C, B
- PLD · di-heneicosanoyl phosphatidyl choline · ligand · 9 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1074 | 0.79 | 0.79 | 87 | empty |
| 2 | 528 | 0.73 | 0.81 | 67 | empty |
| 3 | 563 | 0.71 | 0.80 | 68 | empty |
| 4 | 294 | 0.71 | 0.84 | 41 | PLD |
| 5 | 511 | 0.71 | 0.80 | 64 | empty |
Interfaces
3 interfaces between chains.
- C–B · 1189 Ų buried · 12 hydrogen bonds · protein-protein
- A–B · 1188 Ų buried · 12 hydrogen bonds · protein-protein
- A–C · 1173 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- Q15849 · AlphaFold monomer V2.0 prediction for urea transporter 2 (Q15849) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15849
- Elsewhere: RCSB PDB 8BLO · PDBe 8BLO · UniProt Q15849
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