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Crystal structure of Methanocaldococcus jannaschii two-subunit Fumarate hydratase apo-protein complex

Analyse Crystal structure of Methanocaldococcus jannaschii two-subunit Fumarate… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7XKY
Type: protein
Length: 475 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.46
Source: Methanocaldococcus jannaschii
Molecule: Fumarate hydratase
EC: 4.2.1.2
UniProt: A0A832SUM4, A0A832WL32
Pockets: 2 · best druggability 0.69

Structure

x-ray diffraction · resolution 2.46 · 2 distinct chains · 38% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fumarate hydratase (EC 4.2.1.2)	protein	282	43% helix, 23% strand	A0A832SUM4
B	Fumarate hydratase	protein	193	32% helix, 31% strand	A0A832WL32

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	429	0.69	0.81	81	empty
2	62	0.36	0.78	13	empty

Interfaces

1 interface between chains.

A–B · 1265 Å² buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 11 modified (engineered).

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A832SUM4
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Elsewhere: RCSB PDB 7XKY · PDBe 7XKY · UniProt A0A832SUM4 · UniProt A0A832WL32

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