Research workbench
Crystal structure of GIGANTEA in complex with LKP2
Analyse Crystal structure of GIGANTEA in complex with LKP2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7WA4
- Type
- protein
- Length
- 636 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.5
- Source
- Arabidopsis thaliana
- Molecule
- Protein GIGANTEA; Adagio protein 2
- UniProt
- Q9SQI2, Q8W420
- Ligands
- FMN
- Pockets
- 5 · best druggability 0.76
Structure
x-ray diffraction · resolution 3.5 · 2 distinct chains · 65% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein GIGANTEA | protein | 529 | 73% helix, 0% strand | Q9SQI2 |
| B | Adagio protein 2 | protein | 107 | 25% helix, 39% strand | Q8W420 |
Ligands and binding sites
- FMN · Flavin mononucleotide · ligand · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 184 | 0.76 | 0.91 | 26 | FMN |
| 2 | 149 | 0.44 | 0.75 | 19 | empty |
| 3 | 53 | 0.37 | 0.80 | 16 | empty |
| 4 | 96 | 0.36 | 0.74 | 15 | empty |
| 5 | 55 | 0.28 | 0.74 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 927 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 11 modified, 1 cofactor (engineered, flavinylation).
Compared structures
- 7WA4 · Crystal structure of gigantea in complex with LKP2 · the same entry in another collection · chain A against A, TM-score 1.00
- Q8W420 · AlphaFold monomer V2.0 prediction for adagio protein 2 (Q8W420) · a predicted model of the same protein · chain B against A, TM-score 0.97
- Q9SQI2 · AlphaFold monomer V2.0 prediction for protein gigantea (Q9SQI2) · a predicted model of the same protein · chain A against A, TM-score 0.76
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9SQI2
- Every structure of UniProt Q8W420
- Elsewhere: RCSB PDB 7WA4 · PDBe 7WA4 · UniProt Q9SQI2 · UniProt Q8W420
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.