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Crystal structure of Plasmepsin X from Plasmodium falciparum

Analyse Crystal structure of Plasmepsin X from Plasmodium falciparum in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7TBB
Type: protein
Length: 332 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.85
Source: Plasmodium falciparum
Molecule: Plasmepsin 10
UniProt: Q2KNW6
Ligands: NAG
Pockets: 2 · best druggability 0.61

Structure

x-ray diffraction · resolution 1.85 · 1 distinct chain · 15% helix, 45% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Plasmepsin 10	protein	332	15% helix, 45% strand	Q2KNW6

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A
ACT · Acetate ion · additive · 8 copies · chains A
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	358	0.61	0.77	34	ACT
2	97	0.38	0.75	19	empty

Modifications

Observed in the structure: 3 disulfide, 1 glycan (disulfide, N-glycosylation).

Compared structures

7TBB · Crystal structure of plasmepsin X from plasmodium falciparum · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q2KNW6
Elsewhere: RCSB PDB 7TBB · PDBe 7TBB · UniProt Q2KNW6

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