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Crystal Structure of The Tetramerization Domain (29-147) From Human Voltage-gated Potassium Channel Kv2.1 in P 41 21 2 Space Group
Analyse Crystal Structure of The Tetramerization Domain (29-147) From Human… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7RE5
- Type
- protein
- Length
- 542 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.5
- Source
- Homo sapiens
- Molecule
- Potassium voltage-gated channel subfamily B member 1
- UniProt
- Q14721
- Ligands
- ZN
- Pockets
- 3 · best druggability 0.48
Structure
x-ray diffraction · resolution 2.5 · 4 distinct chains · 36% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Potassium voltage-gated channel subfamily B member 1 | protein | 108 | 38% helix, 19% strand | Q14721 |
| B | Potassium voltage-gated channel subfamily B member 1 | protein | 110 | 35% helix, 19% strand | Q14721 |
| C, E | Potassium voltage-gated channel subfamily B member 1 | protein | 107 | 36% helix, 20% strand | Q14721 |
| D | Potassium voltage-gated channel subfamily B member 1 | protein | 110 | 37% helix, 19% strand | Q14721 |
Ligands and binding sites
- ZN · Zinc ion · metal · 8 copies · chains A, B, C, D, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 265 | 0.48 | 0.73 | 52 | empty |
| 2 | 97 | 0.36 | 0.74 | 24 | empty |
| 3 | 69 | 0.27 | 0.72 | 14 | empty |
Interfaces
5 interfaces between chains.
- D–E · 782 Ų buried · 13 hydrogen bonds · protein-protein
- B–C · 757 Ų buried · 12 hydrogen bonds · protein-protein
- C–D · 755 Ų buried · 13 hydrogen bonds · protein-protein
- A–E · 746 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 742 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 7RE5 · Crystal structure of the tetramerization domain (29-147) from human voltage-gated… · the same entry in another collection · chain E against E, TM-score 1.00
- Q14721 · AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily B member… · a predicted model of the same protein · chain C against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14721
- Elsewhere: RCSB PDB 7RE5 · PDBe 7RE5 · UniProt Q14721
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