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Crystal structure of the Mei-P26 NHL domain

Analyse Crystal structure of the Mei-P26 NHL domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7NYQ
Type: protein
Length: 549 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.6
Source: Drosophila melanogaster
Molecule: Meiotic P26, isoform C
UniProt: M9PH32
Pockets: 4 · best druggability 0.74

Structure

x-ray diffraction · resolution 1.6 · 2 distinct chains · 3% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Meiotic P26, isoform C	protein	273	2% helix, 50% strand	M9PH32
B	Meiotic P26, isoform C	protein	276	4% helix, 49% strand	M9PH32

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	311	0.74	0.86	45	empty
2	499	0.70	0.80	56	empty
3	295	0.63	0.80	42	empty
4	111	0.39	0.75	24	empty

Interfaces

1 interface between chains.

A–B · 522 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

7NYQ · Crystal structure of the mei-P26 nhl domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt M9PH32
Elsewhere: RCSB PDB 7NYQ · PDBe 7NYQ · UniProt M9PH32

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