Research workbench

PALS1 PDZ1 domain with SARS-CoV-1_E PBM complex

Analyse PALS1 PDZ1 domain with SARS-CoV-1_E PBM complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7NTJ
Type: protein
Length: 183 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.74
Source: Homo sapiens; SYNTHETIC CONSTRUCT
Molecule: MAGUK p55 subfamily member 5; Envelope small membrane protein
UniProt: Q8N3R9, P59637
Pockets: 1 · best druggability 0.30

Structure

x-ray diffraction · resolution 1.74 · 3 distinct chains · 18% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, A	MAGUK p55 subfamily member 5	protein	86	20% helix, 41% strand	Q8N3R9
G	Envelope small membrane protein	protein	4	0% helix, 50% strand	P59637
C	Envelope small membrane protein	protein	7	0% helix, 29% strand	P59637

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	67	0.30	0.74	14	empty

Interfaces

3 interfaces between chains.

B–A · 469 Å² buried · 7 hydrogen bonds · protein-protein
A–C · 413 Å² buried · 12 hydrogen bonds · protein-protein
B–G · 403 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

7NTJ · PALS1 PDZ1 domain with SARS-cov-1_E pbm complex · the same entry in another collection · chain A against A, TM-score 1.00
Q8N3R9 · AlphaFold monomer V2.0 prediction for maguk P55 subfamily member 5 (Q8N3R9) · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8N3R9
Every structure of UniProt P59637
Elsewhere: RCSB PDB 7NTJ · PDBe 7NTJ · UniProt Q8N3R9 · UniProt P59637

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