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Crystal Structure of B-cell lymphoma 6 protein BTB domain in complex with ligand 4 at 9.80 MGy X-ray dose

Analyse Crystal Structure of B-cell lymphoma 6 protein BTB domain in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7GVS
Type: protein
Length: 126 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.9
Source: Homo sapiens; SYNTHETIC CONSTRUCT
Molecule: B-cell lymphoma 6 protein; WVIP tetrapeptide
UniProt: P41182
Ligands: A1ACR, CL

Structure

x-ray diffraction · resolution 1.9 · 2 distinct chains · 55% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	B-cell lymphoma 6 protein	protein	122	57% helix, 11% strand	P41182
D	WVIP tetrapeptide	protein	4	0% helix, 25% strand	—

Ligands and binding sites

A1ACR · 5-[(2,5-dichloropyridin-4-yl)amino]-1,3-dihydro-2H-indol-2-one · ligand · chains A
CL · Chloride ion · ion · chains A
DMS · Dimethyl sulfoxide · additive · chains A, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–D · 268 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

P41182 · AlphaFold monomer V2.0 prediction for B-cell lymphoma 6 protein (P41182) · a predicted model of the same protein · chain A against A, TM-score 0.34

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P41182
Elsewhere: RCSB PDB 7GVS · PDBe 7GVS · UniProt P41182

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