Research workbench
Drosophila P5CS filament with glutamate, ATP, and NADPH
Analyse Drosophila P5CS filament with glutamate, ATP, and NADPH in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7F5V
- Type
- protein
- Length
- 2,760 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.6
- Source
- Drosophila melanogaster
- Molecule
- Delta-1-pyrroline-5-carboxylate synthase
- EC
- 2.7.2.11, 1.2.1.41
- UniProt
- Q9VNW6
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · resolution 3.6 · 1 distinct chain · 40% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Delta-1-pyrroline-5-carboxylate synthase (EC 2.7.2.11, 1.2.1.41) | protein | 690 | 40% helix, 15% strand | Q9VNW6 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 946 | 0.84 | 0.85 | 79 | empty |
| 2 | 1025 | 0.82 | 0.84 | 94 | empty |
| 3 | 1050 | 0.82 | 0.84 | 106 | empty |
| 4 | 677 | 0.78 | 0.83 | 41 | empty |
| 5 | 692 | 0.77 | 0.82 | 42 | empty |
Interfaces
6 interfaces between chains.
- B–D · 3713 Ų buried · 44 hydrogen bonds · protein-protein
- A–C · 3713 Ų buried · 44 hydrogen bonds · protein-protein
- B–C · 1717 Ų buried · 15 hydrogen bonds · protein-protein
- A–D · 1716 Ų buried · 15 hydrogen bonds · protein-protein
- A–B · 100 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7F5V · Drosophila P5CS filament with glutamate, ATP, and NADPH · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9VNW6
- Elsewhere: RCSB PDB 7F5V · PDBe 7F5V · UniProt Q9VNW6
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.