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Structure of mumps virus nucleoprotein without C-arm

Analyse Structure of mumps virus nucleoprotein without C-arm in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
7EXA
Type
protein + RNA
Length
380 residues
Chains
2
Method
electron microscopy
Collection
MolNFT v2 / PDB Bank
Contract
0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner
0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution
2.9
Source
Escherichia coli; Mumps virus (strain Jeryl-Lynn)
Molecule
Nucleoprotein; RNA (5'-R(P*UP*UP*UP*UP*UP*U)-3')
UniProt
Q77IS8
Pockets
5 · best druggability 0.61

Structure

electron microscopy · resolution 2.9 · 2 distinct chains · 59% helix, 5% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ANucleoproteinprotein37459% helix, 5% strandQ77IS8
BRNA (5'-R(P*UP*UP*UP*UP*UP*U)-3')rna6——

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
12660.610.8041empty
22980.560.7635empty
3990.380.7521empty
4790.370.7713empty
5810.350.7618empty

Interfaces

1 interface between chains.

  • A–B · 747 Ų buried · 15 hydrogen bonds · protein-nucleic

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