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Crystal structure of Ebinur Lake virus cap snatching endonuclease (D92A mutant)

Analyse Crystal structure of Ebinur Lake virus cap snatching endonuclease (D92A mutant) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7EWZ
Type: protein
Length: 346 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.05
Source: Abbey lake orthobunyavirus
Molecule: Replicase
EC: 2.7.7.48
UniProt: A0A059WLS9
Ligands: MN, CL
Pockets: 2 · best druggability 0.40

Structure

x-ray diffraction · resolution 2.05 · 2 distinct chains · 51% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Replicase (EC 2.7.7.48)	protein	172	52% helix, 14% strand	A0A059WLS9
B	Replicase (EC 2.7.7.48)	protein	174	51% helix, 15% strand	A0A059WLS9

Ligands and binding sites

MN · Manganese (II) ion · metal · 2 copies · chains A, B
CL · Chloride ion · ion · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	82	0.40	0.78	21	empty
2	101	0.36	0.74	21	MN, CL

Interfaces

1 interface between chains.

A–B · 553 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

7EWZ · Crystal structure of ebinur lake virus cap snatching endonuclease (D92A mutant) · the same entry in another collection · chain A against A, TM-score 1.00

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Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A059WLS9
Elsewhere: RCSB PDB 7EWZ · PDBe 7EWZ · UniProt A0A059WLS9

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