Research workbench
Crystal structure of Ebinur Lake virus cap snatching endonuclease (D79A mutant)
Analyse Crystal structure of Ebinur Lake virus cap snatching endonuclease (D79A mutant) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7EWY
- Type
- protein
- Length
- 683 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.01
- Source
- Abbey lake orthobunyavirus
- Molecule
- Replicase
- EC
- 2.7.7.48
- UniProt
- A0A059WLS9
- Pockets
- 6 · best druggability 0.60
Structure
x-ray diffraction · resolution 2.01 · 3 distinct chains · 52% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Replicase (EC 2.7.7.48) | protein | 172 | 52% helix, 14% strand | A0A059WLS9 |
| B | Replicase (EC 2.7.7.48) | protein | 169 | 52% helix, 14% strand | A0A059WLS9 |
| D | Replicase (EC 2.7.7.48) | protein | 170 | 52% helix, 14% strand | A0A059WLS9 |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 411 | 0.60 | 0.76 | 38 | empty |
| 2 | 141 | 0.48 | 0.78 | 22 | empty |
| 3 | 142 | 0.41 | 0.74 | 26 | empty |
| 4 | 81 | 0.35 | 0.75 | 15 | empty |
| 5 | 80 | 0.30 | 0.73 | 19 | empty |
Interfaces
4 interfaces between chains.
- A–D · 553 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 462 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 264 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 190 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7EWY · Crystal structure of ebinur lake virus cap snatching endonuclease (D79A mutant) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A059WLS9
- Elsewhere: RCSB PDB 7EWY · PDBe 7EWY · UniProt A0A059WLS9
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