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Crystal structure of Ebinur Lake virus cap snatching endonuclease (H34A mutant)

Analyse Crystal structure of Ebinur Lake virus cap snatching endonuclease (H34A mutant) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7EWV
Type: protein
Length: 347 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.61
Source: Abbey lake orthobunyavirus
Molecule: Replicase
EC: 2.7.7.48
UniProt: A0A059WLS9
Ligands: MN
Pockets: 1 · best druggability 0.30

Structure

x-ray diffraction · resolution 2.61 · 2 distinct chains · 50% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Replicase (EC 2.7.7.48)	protein	173	52% helix, 14% strand	A0A059WLS9
B	Replicase (EC 2.7.7.48)	protein	174	49% helix, 14% strand	A0A059WLS9

Ligands and binding sites

MN · Manganese (II) ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	76	0.30	0.73	15	MN

Compared structures

7EWV · Crystal structure of ebinur lake virus cap snatching endonuclease (H34A mutant) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A059WLS9
Elsewhere: RCSB PDB 7EWV · PDBe 7EWV · UniProt A0A059WLS9

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