Research workbench

Binding of chloromethyl ketone substrate analogues to crystalline papain

Analyse Binding of chloromethyl ketone substrate analogues to crystalline papain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1PAD
Type: protein
Length: 216 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.8
Source: Carica papaya; SYNTHETIC CONSTRUCT
Molecule: Papain; Acetyl-ala-ala-phe-ala-chloromethylketone inhibitor
EC: 3.4.22.2
UniProt: P00784

Structure

x-ray diffraction · resolution 2.8 · 2 distinct chains · 24% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Papain (EC 3.4.22.2)	protein	212	25% helix, 19% strand	P00784
I	Acetyl-ala-ala-phe-ala-chloromethylketone inhibitor	protein	4	0% helix, 25% strand	—

Interfaces

1 interface between chains.

A–I · 315 Å² buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

1PAD · Binding of chloromethyl ketone substrate analogues to crystalline papain · the same entry in another collection · chain A against A, TM-score 1.00
P00784 · AlphaFold monomer V2.0 prediction for papain (P00784) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00784
Elsewhere: RCSB PDB 1PAD · PDBe 1PAD · UniProt P00784

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.