Research workbench
Structure of Csy-AcrIF5
Analyse Structure of Csy-AcrIF5 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7EQG
- Type
- protein + DNA + RNA
- Length
- 3,249 residues
- Chains
- 17
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.2
- Source
- Pseudomonas aeruginosa; SYNTHETIC CONSTRUCT
- Molecule
- CRISPR type I-F/YPEST-associated protein Csy2; CRISPR-associated protein Csy3; AcrIF5…
- UniProt
- B3G161, A0A659BSG0, A0A7M3A7R4, A0A3A8DDU9
- Pockets
- 20 · best druggability 0.88
Structure
electron microscopy · resolution 3.2 · 11 distinct chains · 24% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | CRISPR type I-F/YPEST-associated protein Csy2 | protein | 305 | 17% helix, 28% strand | B3G161 |
| D | CRISPR-associated protein Csy3 | protein | 309 | 23% helix, 21% strand | A0A659BSG0 |
| E, F, H, I | CRISPR-associated protein Csy3 | protein | 333 | 24% helix, 24% strand | A0A659BSG0 |
| G | CRISPR-associated protein Csy3 | protein | 335 | 25% helix, 23% strand | A0A659BSG0 |
| J, Q, R | AcrIF5 | protein | 77 | 21% helix, 35% strand | A0A7M3A7R4 |
| K, P | AcrIF5 | protein | 78 | 17% helix, 35% strand | A0A7M3A7R4 |
| L | type I-F CRISPR-associated endoribonuclease Cas6/Csy4 | protein | 187 | 24% helix, 12% strand | — |
| M | RNA (60-mer) | rna | 58 | — | — |
| N | DNA (54-mer) | dna | 44 | — | — |
| B | Type I-F CRISPR-associated protein Csy1 | protein | 263 | 36% helix, 5% strand | A0A3A8DDU9 |
| O | DNA (54-mer) | dna | 29 | — | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1174 | 0.88 | 0.90 | 186 | empty |
| 2 | 985 | 0.84 | 0.85 | 101 | empty |
| 3 | 922 | 0.84 | 0.86 | 88 | empty |
| 4 | 871 | 0.81 | 0.84 | 95 | empty |
| 5 | 162 | 0.80 | 0.96 | 43 | empty |
Interfaces
56 interfaces between chains.
- C–B · 3600 Ų buried · 29 hydrogen bonds · protein-protein
- H–I · 1879 Ų buried · 15 hydrogen bonds · protein-protein
- F–G · 1841 Ų buried · 15 hydrogen bonds · protein-protein
- C–I · 1840 Ų buried · 18 hydrogen bonds · protein-protein
- G–H · 1824 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 7EQG · Structure of csy-ACRIF5 · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B3G161
- Every structure of UniProt A0A659BSG0
- Every structure of UniProt A0A7M3A7R4
- Every structure of UniProt A0A3A8DDU9
- Elsewhere: RCSB PDB 7EQG · PDBe 7EQG · UniProt B3G161 · UniProt A0A659BSG0 · UniProt A0A7M3A7R4 · UniProt A0A3A8DDU9
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