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Crystal Structure of the Candida Glabrata Glycogen Debranching Enzyme (W470A) in complex with maltohexaose
Analyse Crystal Structure of the Candida Glabrata Glycogen Debranching Enzyme (W470A)… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7EJP
- Type
- protein
- Length
- 3,052 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.1
- Source
- Candida glabrata CBS 138
- Molecule
- 4-alpha-glucanotransferase
- EC
- 2.4.1.25, 3.2.1.33
- UniProt
- Q6FSK0
- Ligands
- GLC
- Pockets
- 20 · best druggability 0.84
Structure
x-ray diffraction · resolution 3.1 · 1 distinct chain · 36% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | 4-alpha-glucanotransferase (EC 2.4.1.25, 3.2.1.33) | protein | 1526 | 36% helix, 16% strand | Q6FSK0 |
Ligands and binding sites
- GLC · alpha-D-glucopyranose · sugar · 20 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 964 | 0.84 | 0.85 | 91 | empty |
| 2 | 1179 | 0.82 | 0.83 | 109 | empty |
| 3 | 80 | 0.73 | 0.96 | 22 | empty |
| 4 | 503 | 0.72 | 0.81 | 60 | empty |
| 5 | 491 | 0.72 | 0.81 | 54 | GLC |
Interfaces
1 interface between chains.
- A–B · 421 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 7EJP · Crystal structure of the candida glabrata glycogen debranching enzyme (W470A) in complex… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6FSK0
- Elsewhere: RCSB PDB 7EJP · PDBe 7EJP · UniProt Q6FSK0
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