Research workbench
Structure of Enolase from Mycobacterium tuberculosis
Analyse Structure of Enolase from Mycobacterium tuberculosis in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7E4X
- Type
- protein
- Length
- 3,384 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.08
- Source
- Mycobacterium tuberculosis
- Molecule
- Enolase
- EC
- 4.2.1.11
- UniProt
- A0A0E8NV14
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · resolution 3.08 · 1 distinct chain · 39% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H | Enolase (EC 4.2.1.11) | protein | 423 | 39% helix, 20% strand | A0A0E8NV14 |
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 821 | 0.81 | 0.84 | 72 | empty |
| 2 | 1033 | 0.80 | 0.81 | 85 | empty |
| 3 | 1031 | 0.79 | 0.81 | 89 | empty |
| 4 | 1118 | 0.79 | 0.81 | 98 | empty |
| 5 | 1040 | 0.76 | 0.79 | 134 | empty |
Interfaces
8 interfaces between chains.
- E–F · 1545 Ų buried · 28 hydrogen bonds · protein-protein
- C–D · 1533 Ų buried · 27 hydrogen bonds · protein-protein
- G–H · 1530 Ų buried · 29 hydrogen bonds · protein-protein
- A–B · 1519 Ų buried · 30 hydrogen bonds · protein-protein
- B–C · 1160 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 7E4X · Structure of enolase from mycobacterium tuberculosis · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0E8NV14
- Elsewhere: RCSB PDB 7E4X · PDBe 7E4X · UniProt A0A0E8NV14
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