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X-ray Crystal structure of PPARgamma R288H mutant.

Analyse X-ray Crystal structure of PPARgamma R288H mutant. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7E2O
Type: protein
Length: 500 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 3.2
Source: Homo sapiens
Molecule: Peroxisome proliferator-activated receptor gamma
UniProt: P37231
Pockets: 6 · best druggability 0.71

Structure

x-ray diffraction · resolution 3.2 · 2 distinct chains · 69% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Peroxisome proliferator-activated receptor gamma	protein	254	71% helix, 5% strand	P37231
B	Peroxisome proliferator-activated receptor gamma	protein	246	67% helix, 5% strand	P37231

Pockets

6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	363	0.71	0.83	44	empty
2	346	0.69	0.82	34	empty
3	388	0.62	0.77	41	empty
4	235	0.54	0.77	22	empty
5	105	0.45	0.78	19	empty

Interfaces

1 interface between chains.

A–B · 970 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

7E2O · X-ray crystal structure of ppargamma R288H mutant. · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P37231
Elsewhere: RCSB PDB 7E2O · PDBe 7E2O · UniProt P37231

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