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Crystal structure of Vibrio fischeri DarR in complex with DNA reveals the transcriptional activation mechanism of LTTR family members

Analyse Crystal structure of Vibrio fischeri DarR in complex with DNA reveals the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7DWO
Type: protein
Length: 584 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.611
Source: Aliivibrio fischeri ES114
Molecule: Predicted DNA-binding transcriptional regulator
UniProt: Q5E4K6
Pockets: 2 · best druggability 0.80

Structure

x-ray diffraction · resolution 2.611 · 1 distinct chain · 43% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Predicted DNA-binding transcriptional regulator	protein	292	43% helix, 23% strand	Q5E4K6

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1091	0.80	0.81	97	empty
2	419	0.60	0.76	34	empty

Interfaces

1 interface between chains.

A–B · 1612 Å² buried · 23 hydrogen bonds · protein-protein

Compared structures

7DWO · Crystal structure of vibrio fischeri darr in complex with DNA reveals the transcriptional… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5E4K6
Elsewhere: RCSB PDB 7DWO · PDBe 7DWO · UniProt Q5E4K6

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