Tetrameric coiled-coil structure of liprin-alpha2_H2

Structure

x-ray diffraction · resolution 2.2 · 4 distinct chains · 93% helix, 0% strand (DSSP).

Ligands and binding sites

• GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

6 interfaces between chains.

• A–B · 1093 Ų buried · 8 hydrogen bonds · protein-protein
• C–D · 1066 Ų buried · 7 hydrogen bonds · protein-protein
• B–D · 725 Ų buried · 2 hydrogen bonds · protein-protein
• A–C · 692 Ų buried · 4 hydrogen bonds · protein-protein
• A–D · 532 Ų buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

• 7D2H · Tetrameric coiled-coil structure of liprin-ALPHA2_H2 · the same entry in another collection · chain D against D, TM-score 1.00
• O75334 · AlphaFold monomer V2.0 prediction for liprin-alpha-2 (O75334) · a predicted model of the same protein · chain C against A, TM-score 0.94

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O75334
• Elsewhere: RCSB PDB 7D2H · PDBe 7D2H · UniProt O75334