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Hsp90 alpha N-terminal domain in complex with a 14 compund

Analyse Hsp90 alpha N-terminal domain in complex with a 14 compund in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7D25
Type: protein
Length: 209 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.65
Source: Mus musculus
Molecule: Heat shock protein HSP 90-alpha
UniProt: P07901
Ligands: GQ6
Pockets: 1 · best druggability 0.71

Structure

x-ray diffraction · resolution 1.65 · 1 distinct chain · 44% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Heat shock protein HSP 90-alpha	protein	209	44% helix, 23% strand	P07901

Ligands and binding sites

GQ6 · 6-chloranyl-9-[(4-methylphenyl)methyl]purin-2-amine · ligand · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	358	0.71	0.83	35	GQ6

Compared structures

7D25 · HSP90 alpha N-terminal domain in complex with a 14 compund · the same entry in another collection · chain A against A, TM-score 1.00
P07901 · AlphaFold monomer V2.0 prediction for heat shock protein HSP 90-alpha (P07901) · a predicted model of the same protein · chain A against A, TM-score 0.81

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07901
Elsewhere: RCSB PDB 7D25 · PDBe 7D25 · UniProt P07901

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