Research workbench
Atrial Natriuretic Peptide Receptor complexed with rat Atrial Natriuretic Peptide
Analyse Atrial Natriuretic Peptide Receptor complexed with rat Atrial Natriuretic… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7BRG
- Type
- protein
- Length
- 877 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.45
- Source
- Rattus norvegicus; SYNTHETIC CONSTRUCT
- Molecule
- Atrial natriuretic peptide receptor 1; Natriuretic peptides A
- EC
- 4.6.1.2
- UniProt
- P18910, P01161
- Ligands
- NAG, MAN, CL
- Pockets
- 10 · best druggability 0.67
Structure
x-ray diffraction · resolution 2.45 · 2 distinct chains · 36% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) | protein | 426 | 38% helix, 19% strand | P18910 |
| L | Natriuretic peptides A | protein | 25 | 12% helix, 4% strand | P01161 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 8 copies · chains A, B
- MAN · alpha-D-mannopyranose · sugar · 6 copies · chains A, B
- CL · Chloride ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 388 | 0.67 | 0.80 | 58 | empty |
| 2 | 300 | 0.66 | 0.82 | 41 | empty |
| 3 | 293 | 0.66 | 0.81 | 39 | empty |
| 4 | 75 | 0.62 | 0.91 | 19 | empty |
| 5 | 75 | 0.62 | 0.90 | 18 | empty |
Interfaces
3 interfaces between chains.
- B–L · 1058 Ų buried · 11 hydrogen bonds · protein-protein
- A–L · 861 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 559 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide, 4 glycan (disulfide, N-glycosylation).
Compared structures
- 7BRG · Atrial natriuretic peptide receptor complexed with rat atrial natriuretic peptide · the same entry in another collection · chain A against A, TM-score 1.00
- P18910 · AlphaFold monomer V2.0 prediction for atrial natriuretic peptide receptor 1 (P18910) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P01161 · AlphaFold monomer V2.0 prediction for natriuretic peptides a (P01161) · a predicted model of the same protein · chain L against A, TM-score 0.22
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18910
- Every structure of UniProt P01161
- Elsewhere: RCSB PDB 7BRG · PDBe 7BRG · UniProt P18910 · UniProt P01161
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