Research workbench
Crystal structure of 2019-nCoV nsp16-nsp10 complex
Analyse Crystal structure of 2019-nCoV nsp16-nsp10 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7BQ7
- Type
- protein
- Length
- 410 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.37
- Source
- Severe acute respiratory syndrome coronavirus 2
- Molecule
- 2'-O-methyltransferase; Non-structural protein 10
- EC
- 2.1.1.-
- UniProt
- P0DTD1
- Ligands
- SAM, ZN
- Pockets
- 6 · best druggability 0.51
Structure
x-ray diffraction · resolution 2.37 · 2 distinct chains · 27% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 2'-O-methyltransferase (EC 2.1.1.-) | protein | 297 | 28% helix, 22% strand | P0DTD1 |
| B | Non-structural protein 10 | protein | 113 | 25% helix, 15% strand | P0DTD1 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 253 | 0.51 | 0.75 | 41 | SAM |
| 2 | 113 | 0.46 | 0.78 | 20 | empty |
| 3 | 59 | 0.37 | 0.79 | 15 | empty |
| 4 | 51 | 0.30 | 0.76 | 14 | empty |
| 5 | 59 | 0.28 | 0.74 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 956 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 7BQ7 · Crystal structure of 2019-ncov NSP16-NSP10 complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0DTD1
- Elsewhere: RCSB PDB 7BQ7 · PDBe 7BQ7 · UniProt P0DTD1
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