Research workbench
Structure of calcium-free mTMEM16A(ac)-I551A chloride channel at 3.3 A resolution
Analyse Structure of calcium-free mTMEM16A(ac)-I551A chloride channel at 3.3 A… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7B5D
- Type
- protein
- Length
- 1,402 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.3
- Source
- Mus musculus
- Molecule
- Anoctamin-1
- UniProt
- Q8BHY3
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · resolution 3.3 · 1 distinct chain · 56% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Anoctamin-1 | protein | 701 | 56% helix, 5% strand | Q8BHY3 |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 453 | 0.83 | 0.90 | 52 | empty |
| 2 | 550 | 0.82 | 0.87 | 64 | empty |
| 3 | 1153 | 0.75 | 0.78 | 91 | empty |
| 4 | 1036 | 0.73 | 0.76 | 64 | empty |
| 5 | 966 | 0.73 | 0.76 | 65 | empty |
Interfaces
1 interface between chains.
- A–B · 1067 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 7B5D · Structure of calcium-free MTMEM16A(AC)-I551A chloride channel at 3.3 a resolution · the same entry in another collection · chain A against A, TM-score 1.00
- Q8BHY3 · AlphaFold monomer V2.0 prediction for anoctamin-1 (Q8BHY3) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8BHY3
- Elsewhere: RCSB PDB 7B5D · PDBe 7B5D · UniProt Q8BHY3
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