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crystal structure of the N-acetylmuramyl-L-alanine amidase, Ami1, from Mycobacterium abscessus bound to L-Alanine-D-isoglutamine
Analyse crystal structure of the N-acetylmuramyl-L-alanine amidase, Ami1, from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7AGO
- Type
- protein
- Length
- 214 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.7
- Source
- Mycobacteroides abscessus
- Molecule
- N-acetylmuramoyl-L-alanine amidase
- UniProt
- A0A418LHZ8
- Ligands
- ZGL, ALA, ZN
- Pockets
- 1 · best druggability 0.59
Structure
x-ray diffraction · resolution 1.7 · 1 distinct chain · 37% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | N-acetylmuramoyl-L-alanine amidase | protein | 214 | 37% helix, 21% strand | A0A418LHZ8 |
Ligands and binding sites
- ZGL · D-alpha-glutamine · ligand · chains A
- ALA · Alanine · ligand · chains A
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 167 | 0.59 | 0.82 | 29 | ZGL, ALA |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7AGO · Crystal structure of the N-acetylmuramyl-L-alanine amidase, AMI1, from mycobacterium… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A418LHZ8
- Elsewhere: RCSB PDB 7AGO · PDBe 7AGO · UniProt A0A418LHZ8
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