Research workbench
Nesprin-2G(aa1425-1649)-FHOD1(aa1-339) complex, H. sapiens
Analyse Nesprin-2G(aa1425-1649)-FHOD1(aa1-339) complex, H. sapiens in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6XF1
- Type
- protein
- Length
- 1,082 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.8
- Source
- Homo sapiens
- Molecule
- Nesprin-2; FH1/FH2 domain-containing protein 1
- UniProt
- Q8WXH0, Q9Y613
- Pockets
- 11 · best druggability 0.72
Structure
x-ray diffraction · resolution 2.8 · 4 distinct chains · 71% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nesprin-2 | protein | 230 | 83% helix, 0% strand | Q8WXH0 |
| B | FH1/FH2 domain-containing protein 1 | protein | 307 | 64% helix, 5% strand | Q9Y613 |
| C | Nesprin-2 | protein | 224 | 83% helix, 0% strand | Q8WXH0 |
| D | FH1/FH2 domain-containing protein 1 | protein | 321 | 62% helix, 7% strand | Q9Y613 |
Pockets
11 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 309 | 0.72 | 0.84 | 33 | empty |
| 2 | 566 | 0.71 | 0.79 | 62 | empty |
| 3 | 111 | 0.63 | 0.87 | 24 | empty |
| 4 | 294 | 0.61 | 0.79 | 39 | empty |
| 5 | 249 | 0.61 | 0.80 | 29 | empty |
Interfaces
5 interfaces between chains.
- C–D · 1253 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 1209 Ų buried · 16 hydrogen bonds · protein-protein
- A–D · 92 Ų buried · 0 hydrogen bonds · protein-protein
- B–D · 35 Ų buried · 0 hydrogen bonds · protein-protein
- A–C · 11 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6XF1 · Nesprin-2G(AA1425-1649)-FHOD1(AA1-339) complex, H. sapiens · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Y613 · AlphaFold monomer V2.0 prediction for FH1/FH2 domain-containing protein 1 (Q9Y613) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8WXH0
- Every structure of UniProt Q9Y613
- Elsewhere: RCSB PDB 6XF1 · PDBe 6XF1 · UniProt Q8WXH0 · UniProt Q9Y613
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