Research workbench
Crystal Structure of mTEAD with a VGL4 Tertiary Structure Mimetic
Analyse Crystal Structure of mTEAD with a VGL4 Tertiary Structure Mimetic in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6SBA
- Type
- protein
- Length
- 232 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.3
- Source
- Mus musculus; SYNTHETIC CONSTRUCT
- Molecule
- Transcriptional enhancer factor TEF-3; Vestigial like 4 (Drosophila), isoform CRA_a
- UniProt
- Q62296, Q3TQI9
- Ligands
- ACE
- Pockets
- 3 · best druggability 0.32
Structure
x-ray diffraction · resolution 1.3 · 2 distinct chains · 25% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcriptional enhancer factor TEF-3 | protein | 212 | 19% helix, 50% strand | Q62296 |
| B | Vestigial like 4 (Drosophila), isoform CRA_a | protein | 20 | 90% helix, 0% strand | Q3TQI9 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 66 | 0.32 | 0.75 | 20 | empty |
| 2 | 55 | 0.28 | 0.73 | 15 | GOL |
| 3 | 58 | 0.26 | 0.73 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 541 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 covalent, 1 isopeptide, 1 modified (covalent ligand, isopeptide, nonstandard).
Compared structures
- 6SBA · Crystal structure of mtead with a VGL4 tertiary structure mimetic · the same entry in another collection · chain A against A, TM-score 1.00
- Q62296 · AlphaFold monomer V2.0 prediction for transcriptional enhancer factor tef-3 (Q62296) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q62296
- Every structure of UniProt Q3TQI9
- Elsewhere: RCSB PDB 6SBA · PDBe 6SBA · UniProt Q62296 · UniProt Q3TQI9
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