Research workbench
T. brucei farnesyl pyrophosphate synthase (FPPS)
Analyse T. brucei farnesyl pyrophosphate synthase (FPPS) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6R36
- Type
- protein
- Length
- 324 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.67
- Source
- Trypanosoma brucei
- Molecule
- Farnesyl pyrophosphate synthase
- UniProt
- Q86C09
- Pockets
- 2 · best druggability 0.66
Structure
x-ray diffraction · resolution 1.67 · 1 distinct chain · 81% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Farnesyl pyrophosphate synthase | protein | 324 | 81% helix, 0% strand | Q86C09 |
Ligands and binding sites
- DMS · Dimethyl sulfoxide · additive · 2 copies · chains A
- PEG · Di(hydroxyethyl)ether · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 546 | 0.66 | 0.77 | 50 | DMS |
| 2 | 58 | 0.31 | 0.75 | 10 | empty |
Compared structures
- 6R36 · T. brucei farnesyl pyrophosphate synthase (fpps) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q86C09
- Elsewhere: RCSB PDB 6R36 · PDBe 6R36 · UniProt Q86C09
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