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Structure of the H1 domain of human KCTD12

Analyse Structure of the H1 domain of human KCTD12 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6QZL
Type: protein
Length: 490 residues
Chains: 5
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.98
Source: Homo sapiens
Molecule: BTB/POZ domain-containing protein KCTD12
UniProt: Q96CX2
Pockets: 3 · best druggability 0.75

Structure

x-ray diffraction · resolution 1.98 · 5 distinct chains · 21% helix, 46% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	BTB/POZ domain-containing protein KCTD12	protein	103	20% helix, 50% strand	Q96CX2
B	BTB/POZ domain-containing protein KCTD12	protein	98	21% helix, 45% strand	Q96CX2
C	BTB/POZ domain-containing protein KCTD12	protein	100	21% helix, 45% strand	Q96CX2
D	BTB/POZ domain-containing protein KCTD12	protein	96	22% helix, 44% strand	Q96CX2
E	BTB/POZ domain-containing protein KCTD12	protein	93	23% helix, 45% strand	Q96CX2

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	621	0.75	0.82	67	empty
2	71	0.42	0.81	16	empty
3	125	0.42	0.76	28	empty

Interfaces

5 interfaces between chains.

B–C · 1086 Å² buried · 7 hydrogen bonds · protein-protein
A–D · 1067 Å² buried · 5 hydrogen bonds · protein-protein
C–D · 1003 Å² buried · 6 hydrogen bonds · protein-protein
B–E · 990 Å² buried · 6 hydrogen bonds · protein-protein
A–E · 836 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

6QZL · Structure of the H1 domain of human KCTD12 · the same entry in another collection · chain E against E, TM-score 1.00
Q96CX2 · AlphaFold monomer V2.0 prediction for BTB/POZ domain-containing protein KCTD12 (Q96CX2) · a predicted model of the same protein · chain C against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96CX2
Elsewhere: RCSB PDB 6QZL · PDBe 6QZL · UniProt Q96CX2

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