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X-ray crystal structure of darunavir-resistant HIV-1 protease (P30) in apo state

Analyse X-ray crystal structure of darunavir-resistant HIV-1 protease (P30) in apo state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6OGV
Type: protein
Length: 99 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.57
Source: Human immunodeficiency virus 1
Molecule: Protease
UniProt: O38885
Pockets: 1 · best druggability 0.49

Structure

x-ray diffraction · resolution 1.57 · 1 distinct chain · 4% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protease	protein	99	4% helix, 51% strand	O38885

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	143	0.49	0.78	21	empty

Compared structures

6OGV · X-ray crystal structure of darunavir-resistant HIV-1 protease (P30) in apo state · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O38885
Elsewhere: RCSB PDB 6OGV · PDBe 6OGV · UniProt O38885

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