Research workbench
X-ray crystal structure of metal-dependent transcriptional regulator MtsR
Analyse X-ray crystal structure of metal-dependent transcriptional regulator MtsR in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6O5C
- Type
- protein
- Length
- 419 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.1
- Source
- Streptococcus pyogenes serotype M3
- Molecule
- Putative metal-dependent transcriptional regulator
- UniProt
- A0A0H2UTK0
- Ligands
- MN
- Pockets
- 5 · best druggability 0.77
Structure
x-ray diffraction · resolution 3.1 · 2 distinct chains · 42% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Putative metal-dependent transcriptional regulator | protein | 215 | 46% helix, 20% strand | A0A0H2UTK0 |
| B | Putative metal-dependent transcriptional regulator | protein | 204 | 39% helix, 18% strand | A0A0H2UTK0 |
Ligands and binding sites
- MN · Manganese (II) ion · metal · 4 copies · chains A, B
- PEG · Di(hydroxyethyl)ether · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1181 | 0.77 | 0.79 | 96 | MN |
| 2 | 205 | 0.64 | 0.83 | 28 | empty |
| 3 | 117 | 0.43 | 0.77 | 23 | empty |
| 4 | 63 | 0.36 | 0.78 | 17 | empty |
| 5 | 50 | 0.33 | 0.78 | 12 | PEG |
Interfaces
1 interface between chains.
- A–B · 584 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6O5C · X-ray crystal structure of metal-dependent transcriptional regulator mtsr · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0H2UTK0
- Elsewhere: RCSB PDB 6O5C · PDBe 6O5C · UniProt A0A0H2UTK0
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