Research workbench

Structural Analysis of a Nitrogenase Iron Protein from Methanosarcina acetivorans: Implications for CO2 Capture by a Surface-Exposed [Fe4S4] Cluster

Analyse Structural Analysis of a Nitrogenase Iron Protein from Methanosarcina… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6NZJ
Type: protein
Length: 546 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.4
Source: Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Molecule: Nitrogenase iron protein
EC: 1.18.6.1
UniProt: Q8TJ93
Ligands: SF4, SO4
Pockets: 4 · best druggability 0.79

Structure

x-ray diffraction · resolution 2.4 · 1 distinct chain · 41% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Nitrogenase iron protein (EC 1.18.6.1)	protein	273	41% helix, 16% strand	Q8TJ93

Ligands and binding sites

SF4 · Iron/sulfur cluster · ligand · chains A, B
SO4 · Sulfate ion · ion · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1081	0.79	0.81	84	SO4
2	217	0.68	0.85	44	empty
3	169	0.60	0.83	36	empty
4	71	0.42	0.80	22	SF4

Interfaces

1 interface between chains.

A–B · 1773 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

6NZJ · Structural analysis of a nitrogenase iron protein from methanosarcina acetivorans… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8TJ93
Elsewhere: RCSB PDB 6NZJ · PDBe 6NZJ · UniProt Q8TJ93

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.