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The crystal structure of B. subtilis RsbV/RsbW complex in the hexagonal crystal form
Analyse The crystal structure of B. subtilis RsbV/RsbW complex in the hexagonal crystal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6M37
- Type
- protein
- Length
- 429 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.1
- Source
- Bacillus subtilis (strain 168)
- Molecule
- Serine-protein kinase RsbW; Anti-sigma-B factor antagonist
- EC
- 2.7.11.1
- UniProt
- P17904, P17903
- Pockets
- 3 · best druggability 0.51
Structure
x-ray diffraction · resolution 3.1 · 4 distinct chains · 41% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Serine-protein kinase RsbW (EC 2.7.11.1) | protein | 113 | 44% helix, 31% strand | P17904 |
| B | Anti-sigma-B factor antagonist | protein | 101 | 38% helix, 35% strand | P17903 |
| C | Serine-protein kinase RsbW (EC 2.7.11.1) | protein | 115 | 44% helix, 30% strand | P17904 |
| D | Anti-sigma-B factor antagonist | protein | 100 | 38% helix, 37% strand | P17903 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 141 | 0.51 | 0.80 | 28 | empty |
| 2 | 68 | 0.43 | 0.81 | 17 | empty |
| 3 | 98 | 0.34 | 0.73 | 20 | empty |
Interfaces
5 interfaces between chains.
- A–C · 835 Ų buried · 9 hydrogen bonds · protein-protein
- C–D · 803 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 776 Ų buried · 15 hydrogen bonds · protein-protein
- B–C · 84 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 20 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6M37 · The crystal structure of B. subtilis RSBV/RSBW complex in the hexagonal crystal form · the same entry in another collection · chain D against D, TM-score 1.00
- P17903 · AlphaFold monomer V2.0 prediction for anti-sigma-B factor antagonist (P17903) · a predicted model of the same protein · chain B against A, TM-score 0.96
- P17904 · AlphaFold monomer V2.0 prediction for serine-protein kinase rsbw (P17904) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P17904
- Every structure of UniProt P17903
- Elsewhere: RCSB PDB 6M37 · PDBe 6M37 · UniProt P17904 · UniProt P17903
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