Research workbench
CryoEM structure of Cascade-TniQ complex
Analyse CryoEM structure of Cascade-TniQ complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6LNC
- Type
- protein + RNA
- Length
- 3,507 residues
- Chains
- 11
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.21
- Source
- Vibrio cholerae
- Molecule
- CRISPR RNA (60-mer); CRISPR-associated protein Cas7; CRISPR-associated protein Cas8…
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · resolution 3.21 · 9 distinct chains · 22% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| M | CRISPR RNA (60-mer) | rna | 60 | — | — |
| G | CRISPR-associated protein Cas7 | protein | 337 | 21% helix, 24% strand | — |
| F | CRISPR-associated protein Cas7 | protein | 336 | 21% helix, 23% strand | — |
| E, C | CRISPR-associated protein Cas7 | protein | 337 | 23% helix, 24% strand | — |
| D | CRISPR-associated protein Cas7 | protein | 338 | 18% helix, 23% strand | — |
| B | CRISPR-associated protein Cas7 | protein | 309 | 23% helix, 24% strand | — |
| H | CRISPR-associated protein Cas8 | protein | 504 | 18% helix, 19% strand | — |
| A | CRISPR-associated protein Cas6 | protein | 197 | 14% helix, 11% strand | — |
| J, I | transposition protein TniQ | protein | 376 | 35% helix, 5% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1191 | 0.86 | 0.87 | 120 | empty |
| 2 | 1055 | 0.83 | 0.85 | 106 | empty |
| 3 | 864 | 0.83 | 0.85 | 95 | empty |
| 4 | 179 | 0.82 | 0.97 | 43 | empty |
| 5 | 798 | 0.81 | 0.84 | 61 | empty |
Interfaces
26 interfaces between chains.
- D–C · 2158 Ų buried · 8 hydrogen bonds · protein-protein
- E–D · 2131 Ų buried · 17 hydrogen bonds · protein-protein
- G–F · 2086 Ų buried · 12 hydrogen bonds · protein-protein
- F–E · 2051 Ų buried · 15 hydrogen bonds · protein-protein
- C–B · 1983 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 6LNC · Cryoem structure of cascade-tniq complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6LNC · PDBe 6LNC
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