Research workbench
The structure of the M. tb toxin MazEF-mt1 complex
Analyse The structure of the M. tb toxin MazEF-mt1 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6KYT
- Type
- protein
- Length
- 1,215 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.00101
- Source
- Mycobacterium tuberculosis H37Rv
- Molecule
- Endoribonuclease MazF9; Antitoxin MazE9
- EC
- 3.1.-.-
- UniProt
- P71650, P0CL61
- Pockets
- 12 · best druggability 0.85
Structure
x-ray diffraction · resolution 2.00101 · 11 distinct chains · 35% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Endoribonuclease MazF9 (EC 3.1.-.-) | protein | 110 | 27% helix, 35% strand | P71650 |
| B | Endoribonuclease MazF9 (EC 3.1.-.-) | protein | 120 | 28% helix, 33% strand | P71650 |
| P | Antitoxin MazE9 | protein | 71 | 69% helix, 7% strand | P0CL61 |
| D | Endoribonuclease MazF9 (EC 3.1.-.-) | protein | 119 | 29% helix, 33% strand | P71650 |
| E | Endoribonuclease MazF9 (EC 3.1.-.-) | protein | 113 | 31% helix, 35% strand | P71650 |
| F, C | Antitoxin MazE9 | protein | 73 | 63% helix, 10% strand | P0CL61 |
| G | Endoribonuclease MazF9 (EC 3.1.-.-) | protein | 118 | 25% helix, 33% strand | P71650 |
| H | Endoribonuclease MazF9 (EC 3.1.-.-) | protein | 118 | 25% helix, 33% strand | P71650 |
| J | Endoribonuclease MazF9 (EC 3.1.-.-) | protein | 111 | 27% helix, 35% strand | P71650 |
| K | Endoribonuclease MazF9 (EC 3.1.-.-) | protein | 117 | 26% helix, 33% strand | P71650 |
| Q | Antitoxin MazE9 | protein | 72 | 65% helix, 7% strand | P0CL61 |
Pockets
12 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 925 | 0.85 | 0.87 | 99 | empty |
| 2 | 963 | 0.78 | 0.80 | 86 | empty |
| 3 | 416 | 0.67 | 0.79 | 49 | empty |
| 4 | 135 | 0.46 | 0.78 | 30 | empty |
| 5 | 115 | 0.46 | 0.79 | 22 | empty |
Interfaces
28 interfaces between chains.
- F–C · 1518 Ų buried · 16 hydrogen bonds · protein-protein
- G–C · 1354 Ų buried · 13 hydrogen bonds · protein-protein
- P–Q · 1354 Ų buried · 13 hydrogen bonds · protein-protein
- J–Q · 1276 Ų buried · 13 hydrogen bonds · protein-protein
- A–P · 1245 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 6KYT · The structure of the M. tb toxin mazef-MT1 complex · the same entry in another collection · chain Q against Q, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P71650
- Every structure of UniProt P0CL61
- Elsewhere: RCSB PDB 6KYT · PDBe 6KYT · UniProt P71650 · UniProt P0CL61
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