Research workbench

Streptococcus pneumoniae Hyaluronate Lyase W292A Mutant

Analyse Streptococcus pneumoniae Hyaluronate Lyase W292A Mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1N7N
Type: protein
Length: 721 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.55
Source: Streptococcus pneumoniae
Molecule: Hyaluronidase
EC: 4.2.2.1
UniProt: Q54873
Pockets: 9 · best druggability 0.74

Structure

x-ray diffraction · resolution 1.55 · 1 distinct chain · 36% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hyaluronidase (EC 4.2.2.1)	protein	721	36% helix, 26% strand	Q54873

Pockets

9 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	938	0.74	0.77	65	empty
2	98	0.44	0.78	20	empty
3	58	0.39	0.80	21	empty
4	82	0.38	0.78	14	empty
5	78	0.35	0.76	18	empty

Compared structures

1N7N · Streptococcus pneumoniae hyaluronate lyase W292A mutant · the same entry in another collection · chain A against A, TM-score 1.00
Q54873 · AlphaFold monomer V2.0 prediction for hyaluronate lyase (Q54873) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q54873
Elsewhere: RCSB PDB 1N7N · PDBe 1N7N · UniProt Q54873

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