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Crystal structure of AMPPNP bound Ck1a alpha from C. neoformans

Analyse Crystal structure of AMPPNP bound Ck1a alpha from C. neoformans in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6K77
Type: protein
Length: 330 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.4
Source: Cryptococcus neoformans var. grubii Bt85
Molecule: Casein kinase II subunit alpha
UniProt: A0A226BA59
Ligands: ANP, MG, SO4
Pockets: 3 · best druggability 0.73

Structure

x-ray diffraction · resolution 2.4 · 1 distinct chain · 45% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Casein kinase II subunit alpha	protein	330	45% helix, 15% strand	A0A226BA59

Ligands and binding sites

ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · chains A
MG · Magnesium ion · metal · chains A
SO4 · Sulfate ion · ion · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	500	0.73	0.81	49	ANP, MG, SO4
2	61	0.40	0.81	14	empty
3	58	0.35	0.78	12	empty

Compared structures

6K77 · Crystal structure of amppnp bound CK1A alpha from C. neoformans · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A226BA59
Elsewhere: RCSB PDB 6K77 · PDBe 6K77 · UniProt A0A226BA59

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