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Crystal structure of the human YTHDC2 YTH domain
Analyse Crystal structure of the human YTHDC2 YTH domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6K6U
- Type
- protein
- Length
- 257 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.27
- Source
- Homo sapiens
- Molecule
- 3'-5' RNA helicase YTHDC2
- EC
- 3.6.4.13
- UniProt
- Q9H6S0
- Pockets
- 3 · best druggability 0.53
Structure
x-ray diffraction · resolution 2.27 · 2 distinct chains · 33% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 3'-5' RNA helicase YTHDC2 (EC 3.6.4.13) | protein | 129 | 33% helix, 30% strand | Q9H6S0 |
| B | 3'-5' RNA helicase YTHDC2 (EC 3.6.4.13) | protein | 128 | 33% helix, 30% strand | Q9H6S0 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 133 | 0.53 | 0.81 | 32 | empty |
| 2 | 63 | 0.29 | 0.74 | 13 | empty |
| 3 | 66 | 0.28 | 0.73 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 414 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H6S0
- Elsewhere: RCSB PDB 6K6U · PDBe 6K6U · UniProt Q9H6S0
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