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Crystal structure of 10-Hydroxygeraniol Dehydrogenase from Cantharanthus roseus in complex with NADP+

Analyse Crystal structure of 10-Hydroxygeraniol Dehydrogenase from Cantharanthus roseus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6K3G
Type: protein
Length: 356 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.41
Source: Catharanthus roseus
Molecule: 10-hydroxygeraniol oxidoreductase
UniProt: A0A067YF90
Ligands: NAP, ZN
Pockets: 3 · best druggability 0.72

Structure

x-ray diffraction · resolution 2.41 · 1 distinct chain · 31% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	10-hydroxygeraniol oxidoreductase	protein	356	31% helix, 28% strand	A0A067YF90

Ligands and binding sites

NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · chains B
ZN · Zinc ion · metal · 2 copies · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	492	0.72	0.81	58	NAP
2	55	0.70	0.98	17	empty
3	51	0.29	0.75	16	empty

Compared structures

6K3G · Crystal structure of 10-hydroxygeraniol dehydrogenase from cantharanthus roseus in… · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A067YF90
Elsewhere: RCSB PDB 6K3G · PDBe 6K3G · UniProt A0A067YF90

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