Research workbench
Aspergillus oryzae pro-tyrosinase oxygen-bound C92A/H103F mutant
Analyse Aspergillus oryzae pro-tyrosinase oxygen-bound C92A/H103F mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6JUC
- Type
- protein
- Length
- 1,086 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.44
- Source
- Aspergillus oryzae
- Molecule
- Tyrosinase
- EC
- 1.14.18.1
- UniProt
- A0A1S9DK56
- Ligands
- CU, PER
- Pockets
- 10 · best druggability 0.75
Structure
x-ray diffraction · resolution 1.44 · 2 distinct chains · 37% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosinase (EC 1.14.18.1) | protein | 540 | 36% helix, 16% strand | A0A1S9DK56 |
| B | Tyrosinase (EC 1.14.18.1) | protein | 546 | 37% helix, 17% strand | A0A1S9DK56 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 94 | 0.75 | 0.96 | 21 | empty |
| 2 | 436 | 0.72 | 0.82 | 69 | empty |
| 3 | 881 | 0.70 | 0.76 | 88 | empty |
| 4 | 52 | 0.69 | 0.98 | 20 | empty |
| 5 | 196 | 0.49 | 0.76 | 38 | empty |
Interfaces
1 interface between chains.
- A–B · 1608 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 6JUC · Aspergillus oryzae pro-tyrosinase oxygen-bound C92A/H103F mutant · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A1S9DK56
- Elsewhere: RCSB PDB 6JUC · PDBe 6JUC · UniProt A0A1S9DK56
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