Research workbench
Aspergillus oryzae pro-tyrosinase C92A/F513Y mutant
Analyse Aspergillus oryzae pro-tyrosinase C92A/F513Y mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6JU5
- Type
- protein
- Length
- 1,096 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.34
- Source
- Aspergillus oryzae
- Molecule
- Tyrosinase
- EC
- 1.14.18.1
- UniProt
- A0A1S9DK56
- Ligands
- CU
- Pockets
- 14 · best druggability 0.76
Structure
x-ray diffraction · resolution 1.34 · 2 distinct chains · 37% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosinase (EC 1.14.18.1) | protein | 542 | 36% helix, 16% strand | A0A1S9DK56 |
| B | Tyrosinase (EC 1.14.18.1) | protein | 554 | 37% helix, 17% strand | A0A1S9DK56 |
Ligands and binding sites
- CU · Copper (II) ion · metal · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 101 | 0.76 | 0.97 | 28 | empty |
| 2 | 1044 | 0.75 | 0.78 | 93 | empty |
| 3 | 59 | 0.70 | 0.97 | 23 | empty |
| 4 | 59 | 0.68 | 0.96 | 23 | empty |
| 5 | 353 | 0.62 | 0.78 | 56 | empty |
Interfaces
1 interface between chains.
- A–B · 1571 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 6JU5 · Aspergillus oryzae pro-tyrosinase C92A/F513Y mutant · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A1S9DK56
- Elsewhere: RCSB PDB 6JU5 · PDBe 6JU5 · UniProt A0A1S9DK56
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